Type III Secretion Mediated Translocation of Effector Exoenzymes by Pseudomonas aeruginosa
نویسنده
چکیده
1
منابع مشابه
Pseudomonas aeruginosa infection of airway epithelial cells modulates expression of Kruppel-like factors 2 and 6 via RsmA-mediated regulation of type III exoenzymes S and Y.
Pseudomonas aeruginosa is an important opportunistic pathogen which is capable of causing both acute and chronic infections in immunocompromised patients. Successful adaptation of the bacterium to its host environment relies on the ability of the organism to tightly regulate gene expression. RsmA, a small RNA-binding protein, controls the expression of a large number of virulence-related genes ...
متن کاملThe Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1β maturation
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that forms a serious problem for immunocompromised patients and also the leading cause of mortality in cystic fibrosis. The overall importance of a functional Type III secretion system (T3SS) in P. aeruginosa virulence has been well established, but the underlying mechanisms are still unclear. Using in vitro infected macrophages as w...
متن کاملفراوانی ژنهای کد کننده سیتوتوکسینهای exoT، exoY، exoS وexoU سیستم ترشحی تیپ 3 در سودوموناس آئروجینوزا جدا شده از بیماران سوختگی
Background and Objective: Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial burn infections. Disease results from the production of numerous virulence factors, some of which are injected directly into the eukaryotic host cells via the type III secretion system (T3SS).The aim of this study was to determine the prevalence of cytotoxins encoding exoT, exoY, exoS and exoU genes...
متن کاملMolecular Investigation of Outer Membrane Channel Genes Among Multidrug Resistance Clinical Pseudomonas Aeruginosa Isolates
Background: Multidrug resistance Pseudomonas aeruginosa (MDRPA) is most important issue in healthcare setting. It can secrete many virulence effector proteins via its secretion system type (T1SS-T6SS). They are using them as conductor for delivering the effector proteins outside to begins harmful effect on host cell increasing pathogenicity, competition against other microorganism and nutrient ...
متن کاملRole of type III secretory system and related exotoxins in infections induced by an opportunistic pathogen Pseudomonas aeruginosa
The T3SS is a needle-like nanomachine that injects virulence proteins (exotoxins) directly into eukaryotic cells to initiate infection. Fore effector proteins of P. aeruginosa, ExoS, Exo T, Exo U, and ExoY, modulate a variety of cellular functions for the pathogen's benefit via their enzymatic activity. P. aeruginosa is invasive or cytotoxic to host cells, depending on the T3SS effectors encode...
متن کامل